Introduction: The genesis of cancer appears to be a complex matter. which is not simply based upon few genetic abnormalities/alteration. In fact. irregular microvasculature and aberrant interstitium of solid tumors impose significant pathophysiologic barrier functions against cancer treatment modalities. https://www.lightemupsequences.com/quick-find-Our-Seasons-The-World-in-Winter-Spring-Summer-and-Autumn-best-save/