You will find there's launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to lessen afferent ache transmission and make analgesia. Therefore, medicine like clonidine that concentrate on alpha-2 receptors can impact the transmission of pain. One of many theories https://www.proleviate.com/post/the-new-pain-killer-conolidine